A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

BACKGROUND: Patched 1 (Ptc1) is a polytopic receptor protein that is essential for growth and differentiation. Its extracellular domains accept its ligand, Sonic Hedgehog, while the function of its C-terminal intracellular domain is largely obscure. PRINCIPAL FINDINGS: In this study, we stably expre...

Descripción completa

Detalles Bibliográficos
Autores principales: Kagawa, Hiroki, Shino, Yuka, Kobayashi, Daigo, Demizu, Syunsuke, Shimada, Masumi, Ariga, Hiroyoshi, Kawahara, Hiroyuki
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076429/
https://www.ncbi.nlm.nih.gov/pubmed/21533246
http://dx.doi.org/10.1371/journal.pone.0018638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076429/
https://www.ncbi.nlm.nih.gov/pubmed/21533246
http://dx.doi.org/10.1371/journal.pone.0018638

Ejemplares similares