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Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1

BACKGROUND: Members of the Mps1 kinase family play an essential and evolutionarily conserved role in the spindle assembly checkpoint (SAC), a surveillance mechanism that ensures accurate chromosome segregation during mitosis. Human Mps1 (hMps1) is highly phosphorylated during mitosis and many phosph...

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Detalles Bibliográficos
Autores principales: Dou, Zhen, von Schubert, Conrad, Körner, Roman, Santamaria, Anna, Elowe, Sabine, Nigg, Erich A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076450/
https://www.ncbi.nlm.nih.gov/pubmed/21533207
http://dx.doi.org/10.1371/journal.pone.0018793