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Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration
Ion fluxes at the plasma membrane have an important role in early stages of apoptosis. Accordingly, plasma membrane depolarization and gain of Na(+) and loss of K(+) are initial events in apoptosis. We have studied the effect of staurosporine (STS), a well-established apoptosis inducer, on the membr...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077289/ https://www.ncbi.nlm.nih.gov/pubmed/21368885 http://dx.doi.org/10.1038/cddis.2010.93 |