A Systematic Study of Gene Mutations in Urothelial Carcinoma; Inactivating Mutations in TSC2 and PIK3R1

BACKGROUND: Urothelial carcinoma (UC) is characterized by frequent gene mutations of which activating mutations in FGFR3 are the most frequent. Several downstream targets of FGFR3 are also mutated in UC, e.g., PIK3CA, AKT1, and RAS. Most mutation studies of UCs have been focused on single or a few g...

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Detalles Bibliográficos
Autores principales: Sjödahl, Gottfrid, Lauss, Martin, Gudjonsson, Sigurdur, Liedberg, Fredrik, Halldén, Christer, Chebil, Gunilla, Månsson, Wiking, Höglund, Mattias, Lindgren, David
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077383/
https://www.ncbi.nlm.nih.gov/pubmed/21533174
http://dx.doi.org/10.1371/journal.pone.0018583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077383/
https://www.ncbi.nlm.nih.gov/pubmed/21533174
http://dx.doi.org/10.1371/journal.pone.0018583

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