Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

The Notch signaling pathway is essential for normal development due to its role in control of cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis and cancer progression. A key enzyme in the activation of Notch signaling is the gamma-secretase protein com...

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Detalles Bibliográficos
Autores principales: Kalén, Mattias, Heikura, Tommi, Karvinen, Henna, Nitzsche, Anja, Weber, Holger, Esser, Norbert, Ylä-Herttuala, Seppo, Hellström, Mats
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077402/
https://www.ncbi.nlm.nih.gov/pubmed/21533193
http://dx.doi.org/10.1371/journal.pone.0018709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077402/
https://www.ncbi.nlm.nih.gov/pubmed/21533193
http://dx.doi.org/10.1371/journal.pone.0018709

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