A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore

Two-pore domain potassium (K(2P)) channels play a key role in setting the membrane potential of excitable cells. Despite their role as putative targets for drugs and general anesthetics, little is known about the structure and the drug binding site of K(2P) channels. We describe A1899 as a potent an...

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Detalles Bibliográficos
Autores principales: Streit, Anne K., Netter, Michael F., Kempf, Franca, Walecki, Magdalena, Rinné, Susanne, Bollepalli, Murali K., Preisig-Müller, Regina, Renigunta, Vijay, Daut, Jürgen, Baukrowitz, Thomas, Sansom, Mark S. P., Stansfeld, Phillip J., Decher, Niels
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077598/
https://www.ncbi.nlm.nih.gov/pubmed/21362619
http://dx.doi.org/10.1074/jbc.M111.227884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077598/
https://www.ncbi.nlm.nih.gov/pubmed/21362619
http://dx.doi.org/10.1074/jbc.M111.227884

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