Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

[Image: see text] Rhomboids are relatively recently discovered intramembrane serine proteases that are conserved throughout evolution. They have a wide range of biological functions, and there is also much speculation about their potential medical relevance. Although rhomboids are weakly inhibited b...

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Detalles Bibliográficos
Autores principales: Pierrat, Olivier A., Strisovsky, Kvido, Christova, Yonka, Large, Jonathan, Ansell, Keith, Bouloc, Nathalie, Smiljanic, Ela, Freeman, Matthew
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077804/
https://www.ncbi.nlm.nih.gov/pubmed/21175222
http://dx.doi.org/10.1021/cb100314y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077804/
https://www.ncbi.nlm.nih.gov/pubmed/21175222
http://dx.doi.org/10.1021/cb100314y

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