LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in C. elegans

The highly conserved let-7 microRNA (miRNA) regulates developmental pathways across animal phyla. Mis-expression of let-7 causes lethality in Caenorhabditis elegans and has been associated with several human diseases. We show that timing of let-7 expression in developing worms is under complex trans...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Wynsberghe, Priscilla M., Kai, Zoya S., Massirer, Katlin B., Burton, Victoria H., Yeo, Gene W., Pasquinelli, Amy E.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077891/
https://www.ncbi.nlm.nih.gov/pubmed/21297634
http://dx.doi.org/10.1038/nsmb.1986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077891/
https://www.ncbi.nlm.nih.gov/pubmed/21297634
http://dx.doi.org/10.1038/nsmb.1986

Ejemplares similares