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LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in C. elegans
The highly conserved let-7 microRNA (miRNA) regulates developmental pathways across animal phyla. Mis-expression of let-7 causes lethality in Caenorhabditis elegans and has been associated with several human diseases. We show that timing of let-7 expression in developing worms is under complex trans...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077891/ https://www.ncbi.nlm.nih.gov/pubmed/21297634 http://dx.doi.org/10.1038/nsmb.1986 |