Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

Caspase-8 has two opposing biological functions - it promotes cell death by triggering the extrinsic pathway of apoptosis, but also has a survival activity, as it is required for embryonic development1, T lymphocyte activation2, and resistance to necrosis induced by Tumor Necrosis Factor-α (TNF) and...

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Detalles Bibliográficos
Autores principales: Oberst, Andrew, Dillon, Christopher P., Weinlich, Ricardo, McCormick, Laura L., Fitzgerald, Patrick, Pop, Cristina, Hakem, Razq, Salvesen, Guy S., Green, Douglas R.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077893/
https://www.ncbi.nlm.nih.gov/pubmed/21368763
http://dx.doi.org/10.1038/nature09852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077893/
https://www.ncbi.nlm.nih.gov/pubmed/21368763
http://dx.doi.org/10.1038/nature09852

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