Transcription factor T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the RORγt gene

Overactive T(H)17 responses are tightly linked to the development of autoimmunity, yet the factors that negatively regulate differentiation of this lineage remain unknown. Here, we report that T-bet suppresses the development of the T(H)17 cell lineage by inhibiting the transcription of Rorc. T-bet...

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Detalles Bibliográficos
Autores principales: Lazarevic, Vanja, Chen, Xi, Shim, Jae-Hyuck, Hwang, Eun-Sook, Jang, Eunjung, Bolm, Alexandra N., Oukka, Mohamed, Kuchroo, Vijay K., Glimcher, Laurie H.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077962/
https://www.ncbi.nlm.nih.gov/pubmed/21151104
http://dx.doi.org/10.1038/ni.1969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077962/
https://www.ncbi.nlm.nih.gov/pubmed/21151104
http://dx.doi.org/10.1038/ni.1969

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