The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation

BACKGROUND: NPC1L1 is the molecular target of the cholesterol lowering drug Ezetimibe and mediates the intestinal absorption of cholesterol. Inhibition or deletion of NPC1L1 reduces intestinal cholesterol absorption, resulting in reduction of plasma cholesterol levels. PRINCIPAL FINDINGS: Here we pr...

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Detalles Bibliográficos
Autores principales: Kwon, Hyock Joo, Palnitkar, Maya, Deisenhofer, Johann
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078110/
https://www.ncbi.nlm.nih.gov/pubmed/21525977
http://dx.doi.org/10.1371/journal.pone.0018722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078110/
https://www.ncbi.nlm.nih.gov/pubmed/21525977
http://dx.doi.org/10.1371/journal.pone.0018722

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