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Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks
BACKGROUND: Micronuclei (MN) in mammalian cells serve as a reliable biomarker of genomic instability and genotoxic exposure. Elevation of MN is commonly observed in cells bearing intrinsic genomic instability and in normal cells exposed to genotoxic agents. DNA double-strand breaks are marked by pho...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078113/ https://www.ncbi.nlm.nih.gov/pubmed/21525980 http://dx.doi.org/10.1371/journal.pone.0018618 |