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Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

BACKGROUND: Micronuclei (MN) in mammalian cells serve as a reliable biomarker of genomic instability and genotoxic exposure. Elevation of MN is commonly observed in cells bearing intrinsic genomic instability and in normal cells exposed to genotoxic agents. DNA double-strand breaks are marked by pho...

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Detalles Bibliográficos
Autores principales:	Xu, Bing, Sun, Zhaoliang, Liu, Zhaojian, Guo, Haiyang, Liu, Qiao, Jiang, Haiyan, Zou, Yongxin, Gong, Yaoqin, Tischfield, Jay A., Shao, Changshun
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078113/ https://www.ncbi.nlm.nih.gov/pubmed/21525980 http://dx.doi.org/10.1371/journal.pone.0018618

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