Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1

BACKGROUND: Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory sign...

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Detalles Bibliográficos
Autores principales: Go, Young-Mi, Kang, Sang-Moo, Roede, James R., Orr, Michael, Jones, Dean P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078150/
https://www.ncbi.nlm.nih.gov/pubmed/21526215
http://dx.doi.org/10.1371/journal.pone.0018918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078150/
https://www.ncbi.nlm.nih.gov/pubmed/21526215
http://dx.doi.org/10.1371/journal.pone.0018918

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