Cargando…
Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1
BACKGROUND: Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory sign...
| Autores principales: | , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078150/ https://www.ncbi.nlm.nih.gov/pubmed/21526215 http://dx.doi.org/10.1371/journal.pone.0018918 |