Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [(11)C]CIT and target controlled infusion

INTRODUCTION: Occupancy-over-time was determined for two dopamine transporter (DAT) inhibitors through modeling of their ability to displace the PET ligand [(11)C]CIT. The tracer was held at a pseudo steady state in a reference tissue by target controlled infusion. METHODS: Rhesus monkeys (n = 5) we...

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Detalles Bibliográficos
Autores principales: Eriksson, Olof, Långström, Bengt, Josephsson, Ray
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078538/
https://www.ncbi.nlm.nih.gov/pubmed/21443419
http://dx.doi.org/10.3109/03009734.2011.563878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078538/
https://www.ncbi.nlm.nih.gov/pubmed/21443419
http://dx.doi.org/10.3109/03009734.2011.563878

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