Cargando…

Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility

BACKGROUND: Mitochondrial DNA (mtDNA) mutations occur in head and neck squamous cell carcinoma (HNSCC) and are most frequently detected in the displacement-loop (D-loop) region. The D-loop is considered to be important because it controls mitochondrial gene expression and mtDNA replication. There is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Challen, C, Brown, H, Cai, C, Betts, G, Paterson, I, Sloan, P, West, C, Birch-Machin, M, Robinson, M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078603/ https://www.ncbi.nlm.nih.gov/pubmed/21427725 http://dx.doi.org/10.1038/bjc.2011.96

Ejemplares similares

The utility of molecular diagnostics to predict recurrence of head and neck carcinoma
por: Pena Murillo, C, et al.
Publicado: (2012)

Real-time PCR analysis of a 3895 bp mitochondrial DNA deletion in nonmelanoma skin cancer and its use as a quantitative marker for sunlight exposure in human skin
por: Harbottle, A, et al.
Publicado: (2006)

Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma
por: Lièvre, A, et al.
Publicado: (2006)

Circulating microRNAs as prognostic therapy biomarkers in head and neck cancer patients
por: Summerer, I, et al.
Publicado: (2015)

Prolactin receptor is a negative prognostic factor in patients with squamous cell carcinoma of the head and neck
por: Bauernhofer, T, et al.
Publicado: (2011)

Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma
por: Slebos, R J C, et al.
Publicado: (2008)

Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
por: Balermpas, P, et al.
Publicado: (2014)

Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status
por: Hofman, P, et al.
Publicado: (2008)

Diagnosis of head-and-neck cancer from exhaled breath
por: Hakim, M, et al.
Publicado: (2011)

Impact of p16 status on pro- and anti-angiogenesis factors in head and neck cancers
por: Baruah, P, et al.
Publicado: (2015)

Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma
por: Nishimura, K, et al.
Publicado: (2014)

hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells
por: Chang, J T, et al.
Publicado: (2006)

Collagen type XI α1 facilitates head and neck squamous cell cancer growth and invasion
por: Sok, J C, et al.
Publicado: (2013)

Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing
por: Kalirai, H, et al.
Publicado: (2014)

Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer
por: Schaefer, C, et al.
Publicado: (2005)

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
por: Wigfield, S M, et al.
Publicado: (2008)

Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma
por: Keller, J, et al.
Publicado: (2013)

Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma
por: Zhang, H, et al.
Publicado: (2008)

Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer
por: Anderson, K S, et al.
Publicado: (2011)

Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance
por: Gerlach, M M, et al.
Publicado: (2014)

Pemphigus vulgaris antigen mRNA quantification for the staging of sentinel lymph nodes in head and neck cancer
por: Solassol, J, et al.
Publicado: (2010)

SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma
por: Lee, S H, et al.
Publicado: (2014)

Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression
por: Canel, M, et al.
Publicado: (2008)

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance
por: Onesto, C, et al.
Publicado: (2006)

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
por: Shaw, R J, et al.
Publicado: (2009)

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
por: Jie, H-B, et al.
Publicado: (2013)

Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer
por: Sridharan, Vishwajith, et al.
Publicado: (2016)

Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer
por: Zhao, N, et al.
Publicado: (2012)

The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer
por: Lajer, C B, et al.
Publicado: (2012)

Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation
por: Liotta, F, et al.
Publicado: (2015)

The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer
por: Pattje, W J, et al.
Publicado: (2010)

Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck
por: Mayer, Arnulf, et al.
Publicado: (2016)

Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis
por: Häyry, Valtteri, et al.
Publicado: (2018)

ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation
por: Jun, H J, et al.
Publicado: (2008)

Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study
por: Gruber, M, et al.
Publicado: (2014)

Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma
por: Lemos-González, Y, et al.
Publicado: (2007)

Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression
por: Kornfeld, J-W, et al.
Publicado: (2011)

Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix
por: Mayer, A, et al.
Publicado: (2013)

Lack of EGF receptor contributes to drug sensitivity of human germline cells
por: Park, S-J, et al.
Publicado: (2005)

Biliverdin's regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer
por: Zheng, J, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_78pdsc79q6hgoh1oe0o6poqpnv