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Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA synthesis and methylation. The importance of this reaction is demonstrated by the effectiveness of antifolate medi...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers Ltd
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078682/ https://www.ncbi.nlm.nih.gov/pubmed/21629435 http://dx.doi.org/10.2174/138920210793360925 |