Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease

BACKGROUND: Case-control studies typically exclude fatal endpoints from the case set, which we hypothesize will substantially underestimate risk if survival is genotype-dependent. The loss of fatal cases is particularly nontrivial for studies of coronary heart disease (CHD) because of significantly...

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Detalles Bibliográficos
Autores principales: Williams, Paul, Pendyala, Lakshmana, Superko, Robert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078850/
https://www.ncbi.nlm.nih.gov/pubmed/21435211
http://dx.doi.org/10.1186/1471-2350-12-42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078850/
https://www.ncbi.nlm.nih.gov/pubmed/21435211
http://dx.doi.org/10.1186/1471-2350-12-42

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