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C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

The Pd/C–CuI–PPh(3) catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the chloro compounds and methanol. A variety of...

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Detalles Bibliográficos
Autores principales: Gorja, Dhilli Rao, Kumar, K Shiva, Mukkanti, K, Pal, Manojit
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079124/
https://www.ncbi.nlm.nih.gov/pubmed/21512602
http://dx.doi.org/10.3762/bjoc.7.44