DNA Ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

DNA replication and repair in mammalian cells involves three distinct DNA ligases; ligase I (Lig1), ligase III (Lig3) and ligase IV (Lig4)1. Lig3 is considered a key ligase during base excision repair because its stability depends upon its nuclear binding partner Xrcc1, a critical factor for this DN...

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Detalles Bibliográficos
Autores principales: Gao, Yankun, Katyal, Sachin, Lee, Youngsoo, Zhao, Jingfeng, Rehg, Jerold E., Russell, Helen R., McKinnon, Peter J.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079429/
https://www.ncbi.nlm.nih.gov/pubmed/21390131
http://dx.doi.org/10.1038/nature09773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079429/
https://www.ncbi.nlm.nih.gov/pubmed/21390131
http://dx.doi.org/10.1038/nature09773

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