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DNA Ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair
DNA replication and repair in mammalian cells involves three distinct DNA ligases; ligase I (Lig1), ligase III (Lig3) and ligase IV (Lig4)1. Lig3 is considered a key ligase during base excision repair because its stability depends upon its nuclear binding partner Xrcc1, a critical factor for this DN...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079429/ https://www.ncbi.nlm.nih.gov/pubmed/21390131 http://dx.doi.org/10.1038/nature09773 |