9p21 DNA variants associated with Coronary Artery Disease impair IFNγ signaling response

Genome wide association studies (GWAS) have identified SNPs in the 9p21 gene desert associated with coronary artery disease (CAD)1–4 and Type 2 diabetes (T2D)5–7. Despite evidence for a role of the associated interval in neighboring gene regulation8–10, the biological underpinnings of these genetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Harismendy, Olivier, Notani, Dimple, Song, Xiaoyuan, Rahim, Nazli G., Tanasa, Bogdan, Heintzman, Nathaniel, Ren, Bing, Fu, Xiang-Dong, Topol, Eric J., Rosenfeld, Michael G., Frazer, Kelly A.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079517/
https://www.ncbi.nlm.nih.gov/pubmed/21307941
http://dx.doi.org/10.1038/nature09753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079517/
https://www.ncbi.nlm.nih.gov/pubmed/21307941
http://dx.doi.org/10.1038/nature09753

Ejemplares similares