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Habenular α5* nicotinic receptor signaling controls nicotine intake

Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco addiction and lung cancer, but underlying mechanisms are unknown. Here, we report dramatically increased nicotine consumption in mice with null mutation in Chrna...

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Detalles Bibliográficos
Autores principales: Fowler, Christie D., Lu, Qun, Johnson, Paul M., Marks, Michael J., Kenny, Paul J.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079537/
https://www.ncbi.nlm.nih.gov/pubmed/21278726
http://dx.doi.org/10.1038/nature09797