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Neurotransmitter/sodium symporter orthologue LeuT has a single high–affinity substrate site

Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions(1–3), removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders(4), and are...

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Detalles Bibliográficos
Autores principales: Piscitelli, Chayne L., Krishnamurthy, Harini, Gouaux, Eric
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079577/
https://www.ncbi.nlm.nih.gov/pubmed/21179170
http://dx.doi.org/10.1038/nature09581