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Glycated albumin suppresses glucose-induced insulin secretion by impairing glucose metabolism in rat pancreatic β-cells

BACKGROUND: Glycated albumin (GA) is an Amadori product used as a marker of hyperglycemia. In this study, we investigated the effect of GA on insulin secretion from pancreatic β cells. METHODS: Islets were collected from male Wistar rats by collagenase digestion. Insulin secretion in the presence of...

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Detalles Bibliográficos
Autores principales: Shiraki, Takayuki, Miura, Yoshikazu, Sawada, Tokihiko, Okada, Toshie, Sakuraoka, Yuhki, Muto, Takashi, Kubota, Keiichi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079599/
https://www.ncbi.nlm.nih.gov/pubmed/21470398
http://dx.doi.org/10.1186/1743-7075-8-20