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Absence of Ataxin-3 Leads to Enhanced Stress Response in C. elegans
Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein degradation by the ubiquitin-proteasome pathway. C. elegans and mouse ataxin-3 knockout models are v...
Autores principales: | Rodrigues, Ana João, Neves-Carvalho, Andreia, Teixeira-Castro, Andreia, Rokka, Anne, Corthals, Garry, Logarinho, Elsa, Maciel, Patrícia |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079722/ https://www.ncbi.nlm.nih.gov/pubmed/21526185 http://dx.doi.org/10.1371/journal.pone.0018512 |
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