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Breaking Up the C Complex Spliceosome Shows Stable Association of Proteins with the Lariat Intron Intermediate

Spliceosome assembly requires several structural rearrangements to position the components of the catalytic core. Many of these rearrangements involve successive strengthening and weakening of different RNA∶RNA and RNA∶proteins interactions within the complex. To gain insight into the organization o...

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Detalles Bibliográficos
Autores principales: Coltri, Patricia, Effenberger, Kerstin, Chalkley, Robert J., Burlingame, A. L., Jurica, Melissa S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079748/
https://www.ncbi.nlm.nih.gov/pubmed/21526149
http://dx.doi.org/10.1371/journal.pone.0019061