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Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling
The spatiotemporal regulation of E-cadherin expression is important during body plan development and carcinogenesis. We found that Tara (Trio-associated repeat on actin) is enriched in cadherin-based adherens junctions (AJs), and its knockdown in MDCK cells (Tara-KD cells) significantly decreases th...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080255/ https://www.ncbi.nlm.nih.gov/pubmed/21482718 http://dx.doi.org/10.1083/jcb.201009100 |