The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-Catenin

MUC1 is an oncoprotein that is overexpressed in up to 90% of breast carcinomas. A previous in vitro study by our group demonstrated that the cytoplasmic domain of MUC1 (MUC1-CD), the minimal functional unit of MUC1, contributes to the malignant phenotype in cells by binding directly to β-catenin and...

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Detalles Bibliográficos
Autores principales: Li, Yuan, Yi, Haiying, Yao, Yixin, Liao, Xiaodong, Xie, Yiqun, Yang, Jie, Yan, Zheng, Wang, Long, Lu, Shunyuan, Kuang, Ying, Gu, Mingmin, Fei, Jian, Wang, Zhugang, Huang, Lei
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080410/
https://www.ncbi.nlm.nih.gov/pubmed/21533058
http://dx.doi.org/10.1371/journal.pone.0019102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080410/
https://www.ncbi.nlm.nih.gov/pubmed/21533058
http://dx.doi.org/10.1371/journal.pone.0019102

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