Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

Huntington's disease (HD) is caused by an expanded CAG tract in the Interesting transcript 15 (IT15) gene encoding the 350 kDa huntingtin protein. Cellular stresses can trigger the release of huntingtin from the endoplasmic reticulum, allowing huntingtin nuclear entry. Here, we show that endoge...

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Detalles Bibliográficos
Autores principales: Munsie, Lise, Caron, Nicholas, Atwal, Randy Singh, Marsden, Ian, Wild, Edward J., Bamburg, James R., Tabrizi, Sarah J., Truant, Ray
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080606/
https://www.ncbi.nlm.nih.gov/pubmed/21355047
http://dx.doi.org/10.1093/hmg/ddr075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080606/
https://www.ncbi.nlm.nih.gov/pubmed/21355047
http://dx.doi.org/10.1093/hmg/ddr075

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