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In Autoimmune Diabetes Unique Autoreactive T Cells Recognize Insulin Peptides Generated in the Islets of Langerhans
Besides the genetic framework, there are two critical requirements for the development of tissue-specific autoimmune diseases. First, autoreactive T cells need to escape thymic negative selection. Second, they need to find suitable conditions for autoantigen presentation and activation in the target...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080751/ https://www.ncbi.nlm.nih.gov/pubmed/20190756 http://dx.doi.org/10.1038/ni.1850 |