Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo

CCR5 is the major co-receptor used by HIV-1 and individuals homozygous for a 32bp deletion in CCR5 are profoundly resistant to HIV-1 infection. Using engineered zinc finger nucleases (ZFNs), we were able to disrupt the CCR5 gene in human hematopoietic stem/progenitor cells (HSC) at a mean frequency...

Descripción completa

Detalles Bibliográficos
Autores principales: Holt, Nathalia, Wang, Jianbin, Kim, Kenneth, Friedman, Geoffrey, Wang, Xingchao, Taupin, Vanessa, Crooks, Gay M., Kohn, Donald B., Gregory, Philip D., Holmes, Michael C., Cannon, Paula M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080757/
https://www.ncbi.nlm.nih.gov/pubmed/20601939
http://dx.doi.org/10.1038/nbt.1663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080757/
https://www.ncbi.nlm.nih.gov/pubmed/20601939
http://dx.doi.org/10.1038/nbt.1663

Ejemplares similares