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Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo

CCR5 is the major co-receptor used by HIV-1 and individuals homozygous for a 32bp deletion in CCR5 are profoundly resistant to HIV-1 infection. Using engineered zinc finger nucleases (ZFNs), we were able to disrupt the CCR5 gene in human hematopoietic stem/progenitor cells (HSC) at a mean frequency...

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Detalles Bibliográficos
Autores principales:	Holt, Nathalia, Wang, Jianbin, Kim, Kenneth, Friedman, Geoffrey, Wang, Xingchao, Taupin, Vanessa, Crooks, Gay M., Kohn, Donald B., Gregory, Philip D., Holmes, Michael C., Cannon, Paula M.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080757/ https://www.ncbi.nlm.nih.gov/pubmed/20601939 http://dx.doi.org/10.1038/nbt.1663

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