Cargando…
Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo
CONTEXT: Mitochondrial ATP production is important in the regulation of glucose-stimulated insulin secretion. Genetic factors may modulate the capacity of the β-cells to secrete insulin and thereby contribute to the risk of type 2 diabetes. OBJECTIVE: The aim of this study was to identify genetic lo...
Autores principales: | Olsson, Anders H, Rönn, Tina, Ladenvall, Claes, Parikh, Hemang, Isomaa, Bo, Groop, Leif, Ling, Charlotte |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioScientifica
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080761/ https://www.ncbi.nlm.nih.gov/pubmed/21325017 http://dx.doi.org/10.1530/EJE-10-0995 |
Ejemplares similares
-
Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets
por: Olsson, Anders H., et al.
Publicado: (2014) -
Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
por: Jonsson, Anna, et al.
Publicado: (2013) -
Genetic Variation in ATP5O Is Associated with Skeletal Muscle ATP50 mRNA Expression and Glucose Uptake in Young Twins
por: Rönn, Tina, et al.
Publicado: (2009) -
A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion
por: Jonsson, Anna, et al.
Publicado: (2009) -
Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
por: Parikh, Hemang, et al.
Publicado: (2009)