RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells

BACKGROUND: Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand the efficiency of RNA interfering of AS in sensitizing the resistant cancer cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Fe-Lin Lin, Liang, Yu-Fen, Chang, Yuan-Chen, Yo, Hao-Hsin, Wei, Ming-Feng, Shen, Li-Jiuan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080799/
https://www.ncbi.nlm.nih.gov/pubmed/21453546
http://dx.doi.org/10.1186/1423-0127-18-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080799/
https://www.ncbi.nlm.nih.gov/pubmed/21453546
http://dx.doi.org/10.1186/1423-0127-18-25

Ejemplares similares