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RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells

BACKGROUND: Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand the efficiency of RNA interfering of AS in sensitizing the resistant cancer cell...

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Detalles Bibliográficos
Autores principales:	Wu, Fe-Lin Lin, Liang, Yu-Fen, Chang, Yuan-Chen, Yo, Hao-Hsin, Wei, Ming-Feng, Shen, Li-Jiuan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080799/ https://www.ncbi.nlm.nih.gov/pubmed/21453546 http://dx.doi.org/10.1186/1423-0127-18-25

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