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Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

BACKGROUND: The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA...

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Detalles Bibliográficos
Autores principales:	Naguib, Adam, Cooke, James C, Happerfield, Lisa, Kerr, Lucy, Gay, Laura J, Luben, Robert N, Ball, Richard Y, Mitrou, Panagiota N, McTaggart, Alison, Arends, Mark J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080834/ https://www.ncbi.nlm.nih.gov/pubmed/21473780 http://dx.doi.org/10.1186/1471-2407-11-123

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