A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

A type III secretion system (T3SS) in pathogenic Yersinia species functions to translocate Yop effectors, which modulate cytokine production and regulate cell death in macrophages. Distinct pathways of T3SS-dependent cell death and caspase-1 activation occur in Yersinia-infected macrophages. One pat...

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Detalles Bibliográficos
Autores principales: Zheng, Ying, Lilo, Sarit, Brodsky, Igor E., Zhang, Yue, Medzhitov, Ruslan, Marcu, Kenneth B., Bliska, James B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080847/
https://www.ncbi.nlm.nih.gov/pubmed/21533069
http://dx.doi.org/10.1371/journal.ppat.1002026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080847/
https://www.ncbi.nlm.nih.gov/pubmed/21533069
http://dx.doi.org/10.1371/journal.ppat.1002026

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