Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking

AS160 has emerged as a key player in insulin-mediated glucose transport through controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated phosphorylation of sites including the 14-3-3 binding phospho-Thr649 (equivalent to Thr642 in human AS160). To define physiological ro...

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Detalles Bibliográficos
Autores principales: Chen, Shuai, Wasserman, David H., MacKintosh, Carol, Sakamoto, Kei
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081066/
https://www.ncbi.nlm.nih.gov/pubmed/21195350
http://dx.doi.org/10.1016/j.cmet.2010.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081066/
https://www.ncbi.nlm.nih.gov/pubmed/21195350
http://dx.doi.org/10.1016/j.cmet.2010.12.005

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