Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogues as Inhibitors of the Annexin A2−S100A10 Protein Interaction

[Image: see text] S100 proteins are small adaptors that regulate the activity of partner proteins by virtue of direct protein interactions. Here, we describe the first small molecule blockers of the interaction between S100A10 and annexin A2. Molecular docking yielded candidate blockers that were sc...

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Detalles Bibliográficos
Autores principales: Reddy, Tummala R. K., Li, Chan, Guo, Xiaoxia, Myrvang, Helene K., Fischer, Peter M., Dekker, Lodewijk V.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081224/
https://www.ncbi.nlm.nih.gov/pubmed/21375334
http://dx.doi.org/10.1021/jm101212e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081224/
https://www.ncbi.nlm.nih.gov/pubmed/21375334
http://dx.doi.org/10.1021/jm101212e

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