High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity

The antigen-binding site of Herceptin, an anti-human Epidermal Growth Factor Receptor 2 (HER2) antibody, was engineered to add a second specificity toward Vascular Endothelial Growth Factor (VEGF) to create a high affinity two-in-one antibody bH1. Crystal structures of bH1 in complex with either ant...

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Detalles Bibliográficos
Autores principales: Bostrom, Jenny, Haber, Lauric, Koenig, Patrick, Kelley, Robert F., Fuh, Germaine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081289/
https://www.ncbi.nlm.nih.gov/pubmed/21526167
http://dx.doi.org/10.1371/journal.pone.0017887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081289/
https://www.ncbi.nlm.nih.gov/pubmed/21526167
http://dx.doi.org/10.1371/journal.pone.0017887

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