Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations

We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensatory and reverting viral mutations, results in increa...

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Detalles Bibliográficos
Autores principales: Huang, Kuan-Hsiang Gary, Goedhals, Dominique, Carlson, Jonathan M., Brockman, Mark A., Mishra, Swati, Brumme, Zabrina L., Hickling, Stephen, Tang, Christopher S. W., Miura, Toshiyuki, Seebregts, Chris, Heckerman, David, Ndung'u, Thumbi, Walker, Bruce, Klenerman, Paul, Steyn, Dewald, Goulder, Philip, Phillips, Rodney, van Vuuren, Cloete, Frater, John
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081339/
https://www.ncbi.nlm.nih.gov/pubmed/21544209
http://dx.doi.org/10.1371/journal.pone.0019018

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