Crystal structure of inhibitor of κB kinase β (IKKβ)

Inhibitor of κB (IκB) kinase (IKK) phosphorylates IκB proteins leading to their degradation and liberation of nuclear factor κB (NF-κB) for gene transcription. Here we report the crystal structure of IKKβ in complex with an inhibitor at 3.6 Å resolution. The structure reveals a tri-modular architect...

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Detalles Bibliográficos
Autores principales: Xu, Guozhou, Lo, Yu-Chih, Li, Qiubai, Napolitano, Gennaro, Wu, Xuefeng, Jiang, Xuliang, Dreano, Michel, Karin, Michael, Wu, Hao
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081413/
https://www.ncbi.nlm.nih.gov/pubmed/21423167
http://dx.doi.org/10.1038/nature09853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081413/
https://www.ncbi.nlm.nih.gov/pubmed/21423167
http://dx.doi.org/10.1038/nature09853

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