Cardioprotective Effect of Nicorandil, a Mitochondrial ATP-Sensitive Potassium Channel Opener, Prolongs Survival in HSPB5 R120G Transgenic Mice

BACKGROUND: Transgenic (TG) mice with overexpression of an arg120gly (R120G) missense mutation in HSPB5 display desmin-related cardiomyopathy, which is characterized by formation of aggresomes. It is also known that progressive mitochondrial abnormalities and apoptotic cell death occur in the hearts...

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Detalles Bibliográficos
Autores principales: Sanbe, Atsushi, Marunouchi, Tetsuro, Yamauchi, Junji, Tanonaka, Kouichi, Nishigori, Hideo, Tanoue, Akito
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081834/
https://www.ncbi.nlm.nih.gov/pubmed/21541347
http://dx.doi.org/10.1371/journal.pone.0018922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081834/
https://www.ncbi.nlm.nih.gov/pubmed/21541347
http://dx.doi.org/10.1371/journal.pone.0018922

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