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Full-Length L1CAM and Not Its Δ2Δ27 Splice Variant Promotes Metastasis through Induction of Gelatinase Expression

Tumour-specific splicing is known to contribute to cancer progression. In the case of the L1 cell adhesion molecule (L1CAM), which is expressed in many human tumours and often linked to bad prognosis, alternative splicing results in a full-length form (FL-L1CAM) and a splice variant lacking exons 2...

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Detalles Bibliográficos
Autores principales: Hauser, Stephanie, Bickel, Laura, Weinspach, Dirk, Gerg, Michael, Schäfer, Michael K., Pfeifer, Marco, Hazin, John, Schelter, Florian, Weidle, Ulrich H., Ramser, Juliane, Volkmann, Juliane, Meindl, Alfons, Schmitt, Manfred, Schrötzlmair, Florian, Altevogt, Peter, Krüger, Achim
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081839/
https://www.ncbi.nlm.nih.gov/pubmed/21541352
http://dx.doi.org/10.1371/journal.pone.0018989