Cargando…

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments

Runx1 controls hematopoietic stem cell emergence and hair follicle stem cell (HFSC) activation and proliferation in adult skin. Here we use lineage tracing and mouse genetic manipulation to address the role of Runx1 in the embryonic development of HFSCs. We find Runx1 is expressed in distinct classe...

Descripción completa

Detalles Bibliográficos
Autores principales: Osorio, Karen M., Lilja, Karin C., Tumbar, Tudorita
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082184/
https://www.ncbi.nlm.nih.gov/pubmed/21464233
http://dx.doi.org/10.1083/jcb.201006068
_version_ 1782202272403423232
author Osorio, Karen M.
Lilja, Karin C.
Tumbar, Tudorita
author_facet Osorio, Karen M.
Lilja, Karin C.
Tumbar, Tudorita
author_sort Osorio, Karen M.
collection PubMed
description Runx1 controls hematopoietic stem cell emergence and hair follicle stem cell (HFSC) activation and proliferation in adult skin. Here we use lineage tracing and mouse genetic manipulation to address the role of Runx1 in the embryonic development of HFSCs. We find Runx1 is expressed in distinct classes of embryonic skin precursors for short-term HF progenitors, adult HFSCs, and mesenchymal progenitors. Runx1 acts in the embryonic epithelium for timely emergence of adult HFSCs and short-term progenitors, but is dispensable for both of them. In contrast, Runx1 is strictly needed in the embryonic mesenchyme for proper adult HFSC differentiation and long-term skin integrity. Our data implicate Runx1 in epithelial cell adhesion and migration and in regulation of paracrine epithelial–mesenchymal cross talk. The latter involves Lef1 and Wnt signaling modulation in opposing directions from two distinct skin compartments. Thus, a master regulator of hematopoiesis also controls HFSC emergence and maintenance via modulation of bidirectional cross talking between nascent stem cells and their niche.
format Text
id pubmed-3082184
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-30821842011-10-04 Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments Osorio, Karen M. Lilja, Karin C. Tumbar, Tudorita J Cell Biol Research Articles Runx1 controls hematopoietic stem cell emergence and hair follicle stem cell (HFSC) activation and proliferation in adult skin. Here we use lineage tracing and mouse genetic manipulation to address the role of Runx1 in the embryonic development of HFSCs. We find Runx1 is expressed in distinct classes of embryonic skin precursors for short-term HF progenitors, adult HFSCs, and mesenchymal progenitors. Runx1 acts in the embryonic epithelium for timely emergence of adult HFSCs and short-term progenitors, but is dispensable for both of them. In contrast, Runx1 is strictly needed in the embryonic mesenchyme for proper adult HFSC differentiation and long-term skin integrity. Our data implicate Runx1 in epithelial cell adhesion and migration and in regulation of paracrine epithelial–mesenchymal cross talk. The latter involves Lef1 and Wnt signaling modulation in opposing directions from two distinct skin compartments. Thus, a master regulator of hematopoiesis also controls HFSC emergence and maintenance via modulation of bidirectional cross talking between nascent stem cells and their niche. The Rockefeller University Press 2011-04-04 /pmc/articles/PMC3082184/ /pubmed/21464233 http://dx.doi.org/10.1083/jcb.201006068 Text en © 2011 Osorio et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Research Articles
Osorio, Karen M.
Lilja, Karin C.
Tumbar, Tudorita
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
title Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
title_full Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
title_fullStr Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
title_full_unstemmed Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
title_short Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
title_sort runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082184/
https://www.ncbi.nlm.nih.gov/pubmed/21464233
http://dx.doi.org/10.1083/jcb.201006068
work_keys_str_mv AT osoriokarenm runx1modulatesadulthairfolliclestemcellemergenceandmaintenancefromdistinctembryonicskincompartments
AT liljakarinc runx1modulatesadulthairfolliclestemcellemergenceandmaintenancefromdistinctembryonicskincompartments
AT tumbartudorita runx1modulatesadulthairfolliclestemcellemergenceandmaintenancefromdistinctembryonicskincompartments