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Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes
BACKGROUND: A gene's position in regulatory, protein interaction or metabolic networks can be predictive of the strength of purifying selection acting on it, but these relationships are neither universal nor invariably strong. Following work in bacteria, fungi and invertebrate animals, we explo...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082228/ https://www.ncbi.nlm.nih.gov/pubmed/21470417 http://dx.doi.org/10.1186/1471-2148-11-89 |