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HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications

The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially “exhausted” and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex...

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Detalles Bibliográficos
Autores principales: Ndhlovu, Lishomwa C., Leal, Fabio E., Hasenkrug, Aaron M., Jha, Aashish R., Carvalho, Karina I., Eccles-James, Ijeoma G., Bruno, Fernanda R., Vieira, Raphaella G. S., York, Vanessa A., Chew, Glen M., Jones, R. Brad, Tanaka, Yuetsu, Neto, Walter K., Sanabani, Sabri S., Ostrowski, Mario A., Segurado, Aluisio C., Nixon, Douglas F., Kallas, Esper G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082508/
https://www.ncbi.nlm.nih.gov/pubmed/21541358
http://dx.doi.org/10.1371/journal.pntd.0001030